Cholesterol Suppresses Cellular TGF‐beta Responsiveness by Increasing TGF‐beta Receptor Accumulation in Lipid raft/Caveolae Microdomains and Alterring TGF‐beta Binding to TGF‐beta Receptors

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Escaping from the TGFbeta anti-proliferative control.

Transforming growth factor-beta (TGFbeta) has a crucial role in tissue homeostasis and disruption of the TGFbeta pathway has been implicated in many human diseases including cancer. As a potent inhibitor of epithelial cell proliferation, TGFbeta is a tumor suppressor. Tumor cells evade the antitumoral effect of TGFbeta, either by acquiring somatic mutations that blunt TGFbeta signaling or by se...

متن کامل

Informatics approaches to understanding TGFbeta pathway regulation.

In recent years, informatics studies have predicted several new ways in which the transforming growth factor beta (TGFbeta) signaling pathway can be post-translationally regulated. Subsequently, many of these predictions were experimentally validated. These approaches include phylogenetic predictions for the phosphorylation, sumoylation and ubiquitylation of pathway components, as well as kinet...

متن کامل

TGFbeta and miRNA regulation in familial and sporadic breast cancer

The term 'BRCAness' was introduced to identify sporadic malignant tumors sharing characteristics similar to those germline BRCA-related. Among all mechanisms attributable to BRCA1 expression silencing, a major role has been assigned to microRNAs. MicroRNAs role in familial and sporadic breast cancer has been explored but few data are available about microRNAs involvement in homologous recombina...

متن کامل

Contributions by members of the TGFbeta superfamily to lens development.

Members of the TGFbeta superfamily of growth and differentiation factors, including the TGFbeta, BMP, activin and nodal families, play important signaling roles throughout development. This paper summarizes some of the functions of these ligands in lens development. Targeted deletion of the genes encoding one of the BMP receptors, Alk3 (BMP receptor-1A), showed that signaling through this recep...

متن کامل

SECRETOGLOBIN 3A2 SUPPRESSES BLEOMYCIN-INDUCED PULMONARY FIBROSIS BY TGFbeta SIGNALING DOWN-REGULATION

Reiko Kurotani, Satoshi Okumura, Tsutomu Matsubara, Utako Yokoyama, John R. Buckley, Takeshi Tomita, Kyohei Kezuka, Tomokazu Nagano, Dominic Esposito, Troy E. Taylor, William K. Gillette, Yoshihiro Ishikawa, Hiroyuki Abe, Jerrold M. Ward, and Shioko Kimura Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA Cardiovascular Research Institut...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: The FASEB Journal

سال: 2008

ISSN: 0892-6638,1530-6860

DOI: 10.1096/fasebj.22.1_supplement.645.7